TNIP1-mediated TNF-α/NF-κB signalling cascade sustains glioma cell proliferation

As a malignant tumour of the central nervous system, glioma exhibits high incidence and poor prognosis. Although TNIP1 and the TNF-alpha/NF-kappa B axis play key roles in immune diseases and inflammatory responses, their relationship and role in glioma remain unknown. Here, we revealed high levels of TNIP1 and TNF-alpha/NF-kappa B in glioma tissue. Glioma cell proliferation was activated with TNF-alpha treatment and showed extreme sensitivity to the TNF receptor antagonist. Furthermore, loss of TNIP1 disbanded the A20 complex responsible for I kappa B degradation and NF-kappa B nucleus translocation, and consequently erased TNF alpha-induced glioma cell proliferation. Thus, our investigation uncovered a vital function of the TNIP1-mediated TNF-alpha/NF-kappa B axis in glioma cell proliferation and provides novel insight into glioma pathology and diagnosis.