期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 24, 期 1, 页码 530-538出版社
WILEY
DOI: 10.1111/jcmm.14760
关键词
cellular signalling; Gliomas; NF-kappa B; TNF-alpha; TNIP1
资金
- National Natural Science Foundation of China [81660418]
- Key Union Project of Yunnan Provincial Science and Technology Department and Kunming Medical University [2015FA005]
As a malignant tumour of the central nervous system, glioma exhibits high incidence and poor prognosis. Although TNIP1 and the TNF-alpha/NF-kappa B axis play key roles in immune diseases and inflammatory responses, their relationship and role in glioma remain unknown. Here, we revealed high levels of TNIP1 and TNF-alpha/NF-kappa B in glioma tissue. Glioma cell proliferation was activated with TNF-alpha treatment and showed extreme sensitivity to the TNF receptor antagonist. Furthermore, loss of TNIP1 disbanded the A20 complex responsible for I kappa B degradation and NF-kappa B nucleus translocation, and consequently erased TNF alpha-induced glioma cell proliferation. Thus, our investigation uncovered a vital function of the TNIP1-mediated TNF-alpha/NF-kappa B axis in glioma cell proliferation and provides novel insight into glioma pathology and diagnosis.
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