期刊
JOURNAL OF CELL SCIENCE
卷 132, 期 20, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.222992
关键词
Adaptor protein complex; Clathrin; Membrane traffic; Endocytosis; Golgi; Hereditary spastic paraplegia
类别
资金
- Wellcome Trust [086598, 214272]
Adaptor protein (AP) complexes are heterotetramers that select cargo for inclusion into transport vesicles. Five AP complexes (AP-1 to AP-5) have been described, each with a distinct localisation and function. Furthermore, patients with a range of disorders, particularly involving the nervous system, have now been identified with mutations in each of the AP complexes. In many cases this has been correlated with aberrantly localised membrane proteins. In this Cell Science at a Glance article and the accompanying poster, we summarize what is known about the five AP complexes and discuss how this helps to explain the clinical features of the different genetic disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据