期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 31, 期 3, 页码 394-406出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2019.1693882
关键词
Polyhydroxyalkanoates; Nanofibers; Electrospinning; Wound dressing applications
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-2019-06094, RGPIN-2016-05929]
Bacterial infections are a serious issue in wound healing. Extensive use of biocides in wound dressings have raised concerns of biocide resistance and unnecessary harm to normal skin cells. In this paper, we report a new approach to realize bacteria-triggered release of a biocide to the sites of bacterial infections from core-shell polyhydroxyalkanoate (PHA)-based nanofibers prepared by coaxial electrospinning. The hydrophobic PHA-based shell can prevent the biocide from undesirable payload release in physiological environments without pathogens. However, in the presence of pathogens, the PHA-based shell is degraded by the pathogens, and the encapsulated biocide is released. The released biocide subsequently can exert targeted antimicrobial effects on the bacteria. Using Pseudomonas aeruginosa as a model bacterium and dodecyltrimethylammonium chloride as a model biocide, we demonstrated that the core-shell PHA-based nanofibers effectively released encapsulated dodecyltrimethylammonium chloride in the presence of Pseudomonas aeruginosa, resulting in targeted inactivation of Pseudomonas aeruginosa cells.
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