期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 71, 期 4, 页码 1285-1295出版社
IOS PRESS
DOI: 10.3233/JAD-190335
关键词
Assistive technology; dyslexia; posterior cortical atrophy; reading
资金
- Dunhill Medical Trust [R337/0214]
- Department of Health's NIHR Biomedical Centres funding scheme
- Economic and Social Research Council (ESRC)/National Institute for Health Research (NIHR) [ES/K006711/1]
- NIHR Oxford Biomedical Research Centre
- Alzheimer's Research UK [ARUK-NSG2017-4]
- Medical Research Council Clinician Scientist Fellowship [MR/K010395/1]
- European Research Council under the European Union [616905]
- Alzheimer's Society [453 (AS-JF-18-003)]
- HEFCE
- Alzheimer's Research UK Research Fellowship
- ESRC [ES/L001810/1] Funding Source: UKRI
- MRC [MR/K010395/1] Funding Source: UKRI
Background: Progressive reading impairment is an early and debilitating symptom of posterior cortical atrophy (PCA) arising from the progressive deterioration of visual processing skills. Objective: The goal of this study was to test the effectiveness of a purpose-built reading app (ReadClear) co-produced with people living with PCA and designed to reduce the reading difficulties experienced by this population (e.g., getting lost in the page and missing words when reading). Methods: Twenty subjects with PCA were included in a cross-over design home-based study aimed at determining whether ReadClear could 1) enhance the subjective reading experience (reading pleasantness) and 2) improve reading accuracy (reducing the number of reading errors) compared with a sham condition (a standard e-reader). Results: Reading using ReadClear provided a better subjective reading experience than sham (p = 0.018, d = 0.5) and significantly reduced the percentage of reading errors (p < 0.0001, r = 0.82), particularly errors due to omissions (p = 0.01, r = 0.50), repeated words (p = 0.002, r = 0.69), and regressions in the text (p = 0.003, r = 0.69). We found that different kinds of reading errors were related to specific neuropsychological profiles. Conclusion: ReadClear can assist reading in people living with PCA by reducing the number of reading errors and improving the subjective reading experience of users.
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