期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 43, 页码 11955-11968出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b04501
关键词
Pisum sativum L.; pea hulls; UHPLC-LTQ-OrbiTrap-MS; phenolics; bioavailability; metabolites; D-galactose rat model; in vivo antioxidant activities
资金
- key project for science and technology research of Jiangxi province in 2018 [5511, 20182ABC28010]
- Natural Science Foundation of China [31660470]
- Natural Science Foundation of Jiangxi Province of China [20171BBF60047]
- Agriculture & Agri Food Canada (AAFC) [J-001322.001.04, 2927]
- Ontario Research fund (ORF) [RE-08-082]
- AAFC
- Saskatchewan Pulse Growers [40004678]
Increased processing of pulses generates large volumes of hulls, which are known as an excellent source of phenolic antioxidants. However, the bioavailability and in vivo activity of these phenolics are rarely reported. This research was therefore carried out to study the absorption, metabolism, and in vivo antioxidant activities of green pea hull (GPH) phenolics using ultrahigh-pressure liquid chromatography with a linear ion trap-high-resolution Orbitrap mass spectrometry and an oxidative stress rat model. A total of 31 phenolics, including 4 phenolic acids, 24 flavonoids, and 3 other phenolics, were tentatively identified. Ten of these phenolics and 49 metabolites were found in the plasma and urine of rats, which helped to explain the favorable changes by GPH phenolics in key antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and glutathione) and indicators (total antioxidant capacity, malondialdehyde) in the plasma and different tissues of rats. This is the first comprehensive report on dry pea hull phenolics and their bioavailability, metabolic profiles, and mechanisms of in vivo antioxidant activities.
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