期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 43, 页码 12105-12116出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b04851
关键词
dinotefuran; honey bees; sublethal olfaction effects; enantioselective toxicity
资金
- Guangxi Science and Technology Major Projects [AA17202017]
- Guangxi Key Laboratory for Agro-Environment and Agro-Product Safety (2016) [133]
Sublethal exposure to neonicotinoids affects honey bee olfaction, but few studies have investigated the sublethal effects of the enantioselective neonicotinoid dinotefuran on honey bee olfaction. This study assessed the sublethal olfactory toxicity of dinotefuran enantiomers to honey bees. Compared to R-dinotefuran, S-dinotefuran had higher acute oral toxicity, sucrose sensitivity effects, octopamine concentrations, lower learning ability, and memory effects on honey bees. High-throughput circular RNA sequencing of the honey bee brain revealed that R-dinotefuran caused more gene regulatory changes than S-dinotefuran. Gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses demonstrated that the SERCA, Kca, and Maxik genes may be related to the enantioselective effects of dinotefuran isomers on honey bee olfaction. These results indicated that the current ecotoxicological safety knowledge about chiral dinotefuran effects on honey bees should be amended.
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