期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 43, 页码 11969-11976出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b04869
关键词
oolong tea polyphenols; circadian clock; intestinal microbiome; regulation mechanism
资金
- Zhejiang Provincial Natural Science Foundation of China [LY19C200006]
- Key Research and Development Project of Zhejiang Province [2017CO2039, 2018CO2047]
- Scientific Research Foundation of Graduate School of Ningbo University
- K. C. Wong Magna Fund in Ningbo University
Our present study focused on the regulating effect of oolong tea polyphenols (OTPs) on the circadian rhythm of liver and intestinal microbiome. OTP significantly alleviated the disrupted diurnal oscillation and phase shift of the specific intestinal microbiota and liver clock genes in mice induced by constant dark (CD) treatment. Transcriptomics revealed that 1114 genes in the control group and 647 genes in the CD group showed circadian rhythm while 723 genes were rhythmic in the CD-OTP group. The Gene Ontology (GO) database provided significant differences in differentially expressed genes (DEGs) in response to OTP treatment. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched the most DEGs after OTP intervention including Focal adhesion (9 DEGs) and PI3K-Akt signaling pathway (9 DEGs). The present study provided a global view that OTP may alleviate the circadian rhythm disorder of the host, contributing to the improvement of microecology and health.
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