期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 83, 期 -, 页码 1345-1352出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2016.08.033
关键词
Glioma; Rapa; Electrospinning; Nanofiber; Local delivery; Cell viability
资金
- National Natural Science Foundation of China [81472353]
- Taishan Scholars Program of Shandong Province, China [ts201511093, tshw201502056, ts20110814]
- Fundamental Research Funds of Shandong University
- Department of Science & Technology of Shandong Province [2015GGE27101, 2015ZDXX0801A01]
- Norwegian Centre for International Cooperation in Education (SIU) [UTF-2014/10047]
- Qilu Hospital Foundation [26010175616021]
Rapamycin, a mammalian target of rapamycin inhibitor and anti-proliferative agent, is used to treat glioma and other malignancies, but its effectiveness is limited by the fact that it cannot be delivered in a targeted manner to the site of the tumor. To address this issue, we fabricated a mesh via electrospinning using two biodegradable materials, poly(lactic acid) (PLA) and polyethylene oxide (PEO) as a carrier for rapamycin delivery to the tumor. Nanofiber diameter decreased with increasing PLA concentration in the mixed solution. Scanning electron microscopy analysis revealed the smooth and uniform surface morphology of hybrid fibers. Fourier transform infrared spectroscopy analysis demonstrated that rapamycin was encapsulated in the polymer solution; encapsulation efficiency was high and stable over the range of drug concentrations from 0.5-2 wt%. A correlation was observed between sustained release of the drug in vitro and cytotoxicity in cultured glioma cells. These results indicate that the PEO/poly(D, Llactic acid) nanofiber mesh can be used as a targeted delivery system for rapamycin that can limit side effects and prevent locoregional recurrence following surgical resection of glioma. (C) 2016 Elsevier Masson SAS. All rights reserved.
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