期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 81, 期 -, 页码 31-37出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2016.03.037
关键词
Curcumin; Ellagic acid; p53; HeLa cells; Cervical cancer; Apoptosis
资金
- Ramalingaswami Fellowship programme of Department of Biotechnology, Government of India
- DST-PURSE programme
- UGC-SAP
- DST-FIST programme
Cervical cancer and precancerous lesions of the cervix continue to be a global health issue, and the medication for the treatment for chronic HPV infection so far has not been effective. Potential anticancer and anti HPV activities of two known phytochemicals, Curcumin and Ellagic acid were evaluated in HeLa cervical cancer cells. Curcumin is a natural compound found in the root of Curcuma longa plant and Ellagic acid a polyphenol found in fruits of strawberries, raspberries and walnuts. The combination of Curcumin and Ellagic acid at various concentrations showed better anticancer properties than either of the drug when used alone as evidenced by MTT assay. Besides this, Curcumin and Ellagic acid also restore p53, induce ROS formation and DNA damage. Mechanistic study further indicated that Curcumin and Ellagic acid show anti-HPV activity as evidenced by decrease in the HPV E6 oncoprotein on HeLa cells. (C) 2016 Elsevier Masson SAS. All rights reserved.
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