期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 78, 期 -, 页码 121-128出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2016.01.003
关键词
GPR50 receptor; Hypothalamus-pituitary-adrenal axis; Glucocorticoid receptor signaling; Torpor; Neurite outgrowth; Neural progenitor cells
资金
- National 12th Five-year Plan Major Scientific and Technological Special Project for Significant New Drugs Creation project of Novel G protein-coupled receptor targeted drug screening system and key technology research [2012ZX09504001-001]
- Program for New Century Excellent Talents in University [NCET-10-0817]
GPR50 receptor one of the member of G protein-coupled receptors (GPCRs) is extensively expressed in the pituitary, hypothalamus, cortex, midbrain, pons, amygdala, and in several brainstem nuclei. The exact function of this receptor in brain is remains unclear. This review presents current knowledge regarding the function of GPR50 receptor in brain, with a focus on role of this receptor in the hypothalamus-pituitary-adrenal (HPA) axis and the glucocorticoid receptor (GR) signaling, leptin signaling, adaptive thermogenesis, torpor, neurite outgrowth, and self-renewal and neuronal differentiation of neural progenitor cells NPCs. Although the results are encouraging, further research is needed to clarify GPR50 role in neurobiology of mood disorders, adaptive thermogenesis, torpor, and in the pathophysiology of neurological disorders. (C) 2016 Elsevier Masson SAS. All rights reserved.
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