期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 14, 期 -, 页码 8787-8804出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S212907
关键词
metallic nanoparticles; hepatotoxicity; subcellular injury; dysfunctions; toxicity outcome
资金
- National Natural Science Foundation of China [81673218, 21876026, 31671034]
- Student's Platform for Innovation and Entrepreneurship Training Program [201810286142]
- Fundamental Research Funds for the Central Universities [2242018K40021, 2242019K40223]
Metallic nanoparticles (MNPs) are new engineering materials with broad prospects for biomedical applications; thus, their biosafety has drawn great concern. The liver is the main detoxification organ of vertebrates. However, many issues concerning the interactions between MNPs and biological systems (cells and tissues) are unclear, particularly the toxic effects of MNPs on hepatocytes and other liver cells. Numerous researchers have shown that some MNPs can induce decreased cell survival rate, production of reactive oxygen species (ROS), mitochondrial damage, DNA strand breaks, and even autophagy, pyroptosis, apoptosis, or other forms of cell death. Our review focuses on the recent researches on the liver toxicity of MNPs and its mechanisms at cellular and subcellular levels to provide a scientific basis for the subsequent hepatotoxicity studies of MNPs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据