期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ijms20225525
关键词
osteoclast; osteoblast; osteocyte; Wnt; sclerostin; osteoporosis; romosozumab; osteoarthritis; rheumatoid arthritis; skeletal-related events
资金
- Ministry of Education, Cultures, Sports, Science and Technology of Japan [18K16161]
- Grants-in-Aid for Scientific Research [18K16161] Funding Source: KAKEN
Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a cytokine involved in various biological phenomena including ontogeny, morphogenesis, carcinogenesis, and maintenance of stem cells. The Wnt signaling pathway can be classified into two main pathways: canonical and non-canonical. Of these, the canonical Wnt signaling pathway promotes osteogenesis. Sclerostin produced by osteocytes is an inhibitor of this pathway, thereby inhibiting osteogenesis. Recently, osteoporosis treatment using an anti-sclerostin therapy has been introduced. In this review, the basics of Wnt signaling, its role in bone metabolism and its involvement in skeletal disorders have been covered. Furthermore, the clinical significance and future scopes of Wnt signaling in osteoporosis, osteoarthritis, rheumatoid arthritis and neoplasia are discussed.
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