相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Sphk2-/- mice are protected from obesity and insulin resistance
Shwetha Ravichandran et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
Seung-Soon Im et al.
PLOS ONE (2019)
Central role of obesity in endothelial cell dysfunction and cardiovascular risk
Jose Carlos de Lima-Junior et al.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2019)
Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp
Katie A. O'Brien et al.
SCIENTIFIC REPORTS (2019)
Plasma metabolomic profiling of amino acids and polar lipids in Iranian obese adults
Minoo Bagheri et al.
LIPIDS IN HEALTH AND DISEASE (2019)
Regulation of Serum Sphingolipids in Andean Children Born and Living at High Altitude (3775 m)
Pietro Barbacini et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
The Role of Ceramides in Insulin Resistance
Emilia Sokolowska et al.
FRONTIERS IN ENDOCRINOLOGY (2019)
Elevated plasma ceramide levels in post-menopausal women: a crosssectional study
Valentina Vozella et al.
AGING-US (2019)
Ceramide and Regulation of Vascular Tone
Angel Cogolludo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach
Suryaprakash Raichur et al.
MOLECULAR METABOLISM (2019)
An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children
Christian Hellmuth et al.
SCIENTIFIC REPORTS (2019)
Sphingolipids and their metabolism in physiology and disease
Yusuf A. Hannun et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Sphingolipids in inflammatory hypoxia
Ulrike G. Glaser et al.
BIOLOGICAL CHEMISTRY (2018)
Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis
Masayuki Nagahashi et al.
CANCER RESEARCH (2018)
Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease
Burkhard Kleuser
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K/AKT-Nrf2 pathway
Gu Gong et al.
MOLECULAR IMMUNOLOGY (2018)
Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status
Elin Rebecka Carlsson et al.
FRONTIERS IN ENDOCRINOLOGY (2018)
Pro-inflammatory cytokines: The link between obesity and osteoarthritis
Tiantian Wang et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2018)
Sphingolipid metabolism in cancer signalling and therapy
Besim Ogretmen
NATURE REVIEWS CANCER (2018)
Sphingolipids in obesity and related complications
Krishna M. Boini et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2017)
Measuring high-altitude adaptation
Lorna G. Moore
JOURNAL OF APPLIED PHYSIOLOGY (2017)
Dietary sphingomyelin attenuates hepatic steatosis and adipose tissue inflammation in high-fat-diet-induced obese mice
Gregory H. Norris et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2017)
Sphingolipids and Lipoproteins in Health and Metabolic Disorders
Jahangir Iqbal et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)
Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library
Hiroshi Tsugawa et al.
JOURNAL OF CHEMINFORMATICS (2017)
TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans
Daniele Capitanio et al.
SCIENTIFIC REPORTS (2017)
Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans
Leonore Wigger et al.
CELL REPORTS (2017)
Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice
Masatake Matsuoka et al.
SCIENTIFIC REPORTS (2017)
Activation of Sphingolipid Pathway in the Livers of Lipodystrophic Agpat2-/- Mice
Shireesha Sankella et al.
JOURNAL OF THE ENDOCRINE SOCIETY (2017)
Obesity and inflammation: the linking mechanism and the complications
Mohammed S. Ellulu et al.
ARCHIVES OF MEDICAL SCIENCE (2017)
De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose
Francis W. B. Sanders et al.
BIOLOGICAL REVIEWS (2016)
Sphingolipids and mitochondrial apoptosis
Gauri A. Patwardhan et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2016)
Sphingolipids Contribute to Human Atherosclerotic Plaque Inflammation
Andreas Edsfeldt et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)
Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes
Sara Tulipani et al.
CLINICA CHIMICA ACTA (2016)
HPTLC-MALDI MS for (glyco)sphingolipid multiplexing in tissues and blood: A promising strategy for biomarker discovery and clinical applications
Enrica Torretta et al.
ELECTROPHORESIS (2016)
S1P Prophylaxis Mitigates Acute Hypobaric Hypoxia-induced Molecular, Biochemical, and Metabolic Disturbances: A Preclinical Report
Sonam Chawla et al.
IUBMB LIFE (2016)
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia
Kaiqi Sun et al.
NATURE COMMUNICATIONS (2016)
Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters
Christina Eich et al.
SCIENTIFIC REPORTS (2016)
Demographic and clinical variables affecting mid-to late-life trajectories of plasma ceramide and dihydroceramide species
Michelle M. Mielke et al.
AGING CELL (2015)
Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans
Bryan C. Bergman et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2015)
Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity
S. Rodriguez-Cuenca et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)
Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2
Lukasz Japtok et al.
FASEB JOURNAL (2015)
Dihydroceramides: From Bit Players to Lead Actors
Monowarul Mobin Siddique et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Sphingolipids in High Fat Diet and Obesity-Related Diseases
Songhwa Choi et al.
MEDIATORS OF INFLAMMATION (2015)
Ceramides - Lipotoxic Inducers of Metabolic Disorders
Bhagirath Chaurasia et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)
Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer
Isabelle Ader et al.
ONCOTARGET (2015)
Three plasma metabolite signatures for diagnosing high altitude pulmonary edema
Li Guo et al.
SCIENTIFIC REPORTS (2015)
Increased Dihydroceramide/Ceramide Ratio Mediated by Defective Expression of degs1 Impairs Adipocyte Differentiation and Function
Nuria Barbarroja et al.
DIABETES (2015)
Oxidative Stress in Obesity: A Critical Component in Human Diseases
Lucia Marseglia et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels
Yugesh Kharel et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation
Nicolas Tardif et al.
AGING CELL (2014)
Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance
Jing Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)
Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity
Yun Sok Lee et al.
CELL (2014)
Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance
Sarah M. Turpin et al.
CELL METABOLISM (2014)
Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate
Andreas V. Thuy et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)
Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype
Susann Fayyaz et al.
DIABETOLOGIA (2014)
Analysis of glycerophospho-and sphingolipids by CE
Cristina Montealegre et al.
ELECTROPHORESIS (2014)
Application of direct HPTLC-MALDI for the qualitative and quantitative profiling of neutral and acidic glycosphingolipids: The case of NEU3 overexpressing C2C12 murine myoblasts
Enrica Torretta et al.
ELECTROPHORESIS (2014)
Hepatic Cannabinoid-1 Receptors Mediate Diet-Induced Insulin Resistance by Increasing De Novo Synthesis of Long-Chain Ceramides
Resat Cinar et al.
HEPATOLOGY (2014)
Sphingosine-1-phosphate inhibits the adipogenic differentiation of 3T3-L1 preadipocytes
Myung-Hee Moon et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2014)
Lipidomic Analysis of Serum from High Fat Diet Induced Obese Mice
Kristina Eisinger et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Ceramides and Glucosylceramides Are Independent Antagonists of Insulin Signaling
Jose A. Chavez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Exogenous Sphingosine 1-Phosphate Protects Murine Splenocytes Against Hypoxia-Induced Injury
Sonam Chawla et al.
LIPIDS (2014)
Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease
Krzysztof Kurek et al.
LIVER INTERNATIONAL (2014)
Plasma Dihydroceramide Species Associate with Waist Circumference in Mexican American Families
Manju Mamtani et al.
OBESITY (2014)
In Vitro Palmitate Treatment of Myotubes from Postmenopausal Women Leads to Ceramide Accumulation, Inflammation and Affected Insulin Signaling
Julie Abildgaard et al.
PLOS ONE (2014)
Effects of Sex, Age, and Fasting Conditions on Plasma Lipidomic Profiles of Fasted Sprague-Dawley Rats
Kosuke Saito et al.
PLOS ONE (2014)
Hypoxia and fatty liver
Tomohiro Suzuki et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2014)
Hypothalamic S1P/S1PR1 axis controls energy homeostasis
Vagner R. R. Silva et al.
NATURE COMMUNICATIONS (2014)
Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα
Eugenia Morselli et al.
CELL REPORTS (2014)
Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults
H. Hanamatsu et al.
NUTRITION & DIABETES (2014)
Mechanism linking diabetes mellitus and obesity
Abdullah S. Al-Goblan et al.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2014)
Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet
Ian R. Lanza et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: Evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction
Mark J. Dekker et al.
ATHEROSCLEROSIS (2013)
Age-dependent effects of high fat-diet on murine left ventricles: role of palmitate
Anne-Cathleen Aurich et al.
BASIC RESEARCH IN CARDIOLOGY (2013)
The complexity of sphingolipid biosynthesis in the endoplasmic reticulum
Rotem Tidhar et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer
Jie Liang et al.
CANCER CELL (2013)
Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes
Shiori Ito et al.
CORONARY ARTERY DISEASE (2013)
Adiponectin Corrects High-Fat Diet-Induced Disturbances in Muscle Metabolomic Profile and Whole-Body Glucose Homeostasis
Ying Liu et al.
DIABETES (2013)
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
N. Turner et al.
DIABETOLOGIA (2013)
The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice
Clinton R. Bruce et al.
ENDOCRINOLOGY (2013)
Glycosphingolipids: synthesis and functions
Giovanni D'Angelo et al.
FEBS JOURNAL (2013)
Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet
J. T. Brozinick et al.
INTERNATIONAL JOURNAL OF OBESITY (2013)
Sphingosine Kinase 1 Is Regulated by Peroxisome Proliferator-activated Receptor α in Response to Free Fatty Acids and Is Essential for Skeletal Muscle Interleukin-6 Production and Signaling in Diet-induced Obesity
Jessica S. Ross et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Plasma lipid profiling in a large population-based cohort
Jacquelyn M. Weir et al.
JOURNAL OF LIPID RESEARCH (2013)
Plasma ceramides are elevated in female children and adolescents with type 2 diabetes
Ximena Lopez et al.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2013)
Palmitate Diet-induced Loss of Cardiac Caveolin-3: A Novel Mechanism for Lipid-induced Contractile Dysfunction
Catherine J. Knowles et al.
PLOS ONE (2013)
Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1α in Thyroid Follicular Carcinoma Cells
Veronica Kalhori et al.
PLOS ONE (2013)
Plasma Sphingosine-1-Phosphate Is Elevated in Obesity
Greg M. Kowalski et al.
PLOS ONE (2013)
Gender-Specific Metabolomic Profiling of Obesity in Leptin-Deficient ob/ob Mice by 1H NMR Spectroscopy
Eun-Young Won et al.
PLOS ONE (2013)
Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation
Heriberto Rodriguez-Hernandez et al.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2013)
Rapid nanoscale quantitative analysis of plant sphingolipid long-chain bases by GC-MS
Jean-Luc Cacas et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2012)
Analysis of sphingolipids in extracted human plasma using liquid chromatography electrospray ionization tandem mass spectrometry
Hai H. Bui et al.
ANALYTICAL BIOCHEMISTRY (2012)
Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice
Naoki Seito et al.
ARTHRITIS AND RHEUMATISM (2012)
Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate
Yugesh Kharel et al.
BIOCHEMICAL JOURNAL (2012)
Ceramide synthases at the centre of sphingolipid metabolism and biology
Thomas D. Mullen et al.
BIOCHEMICAL JOURNAL (2012)
Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice
Clinton R. Bruce et al.
DIABETES (2012)
Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex
Quan-Jiang Zhang et al.
DIABETES (2012)
Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model
Myung-Hee Moon et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2012)
High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism
Lisa Longato et al.
HEPATOLOGY RESEARCH (2012)
Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis
Benjamin T. Bikman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Glycosphingolipids Regulate Ameloblastin Expression in Dental Epithelial Cells
Y. Kamasaki et al.
JOURNAL OF DENTAL RESEARCH (2012)
Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway
Bradley K. Wacker et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Quantitation of Multiple Sphingolipid Classes Using Normal and Reversed-Phase LC-ESI-MS/MS: Comparative Profiling of Two Cell Lines
M. Athar Masood et al.
LIPIDS (2012)
Sphingolipid Content of Human Adipose Tissue: Relationship to Adiponectin and Insulin Resistance
Agnieszka U. Blachnio-Zabielska et al.
OBESITY (2012)
Sex differences in human adipose tissues - the biology of pear shape
Kalypso Karastergiou et al.
BIOLOGY OF SEX DIFFERENCES (2012)
Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets
Simon A. Young et al.
BIOCHEMISTRY RESEARCH INTERNATIONAL (2012)
Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome
I. Majumdar et al.
ENDOCRINE (2012)
Postmenopausal Hypertension
Licy L. Yanes et al.
AMERICAN JOURNAL OF HYPERTENSION (2011)
Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling
Hariom Yadav et al.
CELL METABOLISM (2011)
Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance
C. Lipina et al.
DIABETOLOGIA (2011)
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
Jacques Amar et al.
EMBO MOLECULAR MEDICINE (2011)
Dihydroceramide-based Response to Hypoxia
Cecilia M. Devlin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Dynamic Modification of Sphingomyelin in Lipid Microdomains Controls Development of Obesity, Fatty Liver, and Type 2 Diabetes
Susumu Mitsutake et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
William L. Holland et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction
Miranda M. Y. Sung et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2011)
Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity
Zhiqiang Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Fat Redistribution Following Suction Lipectomy: Defense of Body Fat and Patterns of Restoration
Teri L. Hernandez et al.
OBESITY (2011)
PI3K and ERK-Induced Rac1 Activation Mediates Hypoxia-Induced HIF-1α Expression in MCF-7 Breast Cancer Cells
Jun Du et al.
PLOS ONE (2011)
Protein modulation in mouse heart under acute and chronic hypoxia
Agnese Vigano et al.
PROTEOMICS (2011)
Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers
Kirstin Mittelstrass et al.
PLOS GENETICS (2011)
Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration
Daniela Danieli-Betto et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)
Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERα-deficient mice
Vicent Ribas et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)
Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption
John R. Ussher et al.
DIABETES (2010)
Critical Role of the Mesenteric Depot Versus Other Intra-abdominal Adipose Depots in the Development of Insulin Resistance in Young Rats
Karyn J. Catalano et al.
DIABETES (2010)
Erythrocytes Serve as a Reservoir for Cellular and Extracellular Sphingosine 1-Phosphate
Constantin Bode et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2010)
Blood sphingolipidomics in healthy humans: impact of sample collection methodology
Samar M. Hammad et al.
JOURNAL OF LIPID RESEARCH (2010)
Role of Sphingolipid Mediator Ceramide in Obesity and Renal Injury in Mice Fed a High-Fat Diet
Krishna M. Boini et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
High fat diet induces ceramide and sphingomyelin formation in rat's liver nuclei
Grzegorz Chocian et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2010)
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity
Roger H. Unger et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)
Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis
Stephane Pallu et al.
ARTHRITIS RESEARCH & THERAPY (2010)
Increase in sphingolipid catabolic enzyme activity during aging
Santosh J. Sacket et al.
ACTA PHARMACOLOGICA SINICA (2009)
Automated Ambient Desorption-Ionization Platform for Surface Imaging Integrated with a Commercial Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
Jaroslav Pol et al.
ANALYTICAL CHEMISTRY (2009)
Sphingosine-1-Phosphate A Novel Nonhypoxic Activator of Hypoxia-Inducible Factor-1 in Vascular Cells
Maude D. Michaud et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)
Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance
Jacob M. Haus et al.
DIABETES (2009)
Central Leptin Regulates Total Ceramide Content and Sterol Regulatory Element Binding Protein-1C Proteolytic Maturation in Rat White Adipose Tissue
Elena Bonzon-Kulichenko et al.
ENDOCRINOLOGY (2009)
Hepatic Ceramide May Mediate Brain Insulin Resistance and Neurodegeneration in Type 2 Diabetes and Non-alcoholic Steatohepatitis
Lascelles E. Lyn-Cook et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Transforming Growth Factor-β/Smad3 Signaling Regulates Insulin Gene Transcription and Pancreatic Islet β-Cell Function
Huei-Min Lin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease
Hong Ma et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2009)
Bioactive sphingolipids: metabolism and function
Nana Bartke et al.
JOURNAL OF LIPID RESEARCH (2009)
Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity
Wei Hu et al.
JOURNAL OF LIPID RESEARCH (2009)
Hypoxia Enhances Sphingosine Kinase 2 Activity and Provokes Sphingosine-1-Phosphate-Mediated Chemoresistance in A549 Lung Cancer Cells
Steffen E. Schnitzer et al.
MOLECULAR CANCER RESEARCH (2009)
Cardiac Health in Women With Metabolic Syndrome: Clinical Aspects and Pathophysiology
Jun Ren et al.
OBESITY (2009)
On-line nano-HPLC/ESI QTOF MS and tandem MS for separation, detection, and structural elucidation of human erythrocytes neutral glycosphingolipid mixture
Stephan Kirsch et al.
ANALYTICAL CHEMISTRY (2008)
Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells
Stephanie Schwalm et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Sphingomyelin synthases regulate production of diacylglycerol at the Golgi
Maristella Villani et al.
BIOCHEMICAL JOURNAL (2008)
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
Cungui Mao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)
Novel genome polymorphisms in BCG vaccine strains and impact on efficacy
Andrea S. Leung et al.
BMC GENOMICS (2008)
Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up
Margreth Grotle et al.
BMC MUSCULOSKELETAL DISORDERS (2008)
Sphingosine Kinase 1: A New Modulator of Hypoxia Inducible Factor 1α during Hypoxia in Human Cancer Cells
Isabelle Ader et al.
CANCER RESEARCH (2008)
Obesity and Free Fatty Acids
Guenther Boden
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2008)
Effect of gender on lipid-induced insulin resistance in obese subjects
Bodil Vistisen et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2008)
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1
Charmi Shah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Role of Body Fat Distribution and the Metabolic Complications of Obesity
Michael D. Jensen
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)
Cutaneous water loss and sphingolipids in the stratum corneum of house sparrows, Passer domesticus L., from desert and mesic environments as determined by reversed phase high-performance liquid chromatography coupled with atmospheric pressure photospray ionization mass spectrometry
Agusti Munoz-Garcia et al.
JOURNAL OF EXPERIMENTAL BIOLOGY (2008)
Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss
Sun Hye Jung et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2008)
Gender-dependent progression of systemic metabolic states in early childhood
Janne Nikkilä et al.
Molecular Systems Biology (2008)
Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages
Lama Noureddine et al.
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2008)
Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia
Agnese Vigano et al.
PROTEOMICS (2008)
Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells
Viviana Anelli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Macrophage infiltration into adipose tissue: initiation, propagation and remodeling
Bonnie K. Surmi et al.
FUTURE LIPIDOLOGY (2008)
HDL and its sphingosine-1-phosphate content in cardioprotection
Petra Keul et al.
HEART FAILURE REVIEWS (2007)
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity
Maria Kolak et al.
DIABETES (2007)
Waist circumference and cardiometabolic risk - A consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; The American Society for Nutrition; And the American Diabetes Association
Samuel Klein et al.
DIABETES CARE (2007)
Direct free fatty acid uptake into human adipocytes in vivo - Relation to body fat distribution
Samyah Shadid et al.
DIABETES (2007)
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity
Johannes M. Aerts et al.
DIABETES (2007)
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
William L. Holland et al.
CELL METABOLISM (2007)
BMI compared with 3-dimensional body shape: the UK National Sizing Survey
Jonathan C. K. Wells et al.
AMERICAN JOURNAL OF CLINICAL NUTRITION (2007)
High-fat diets: Modeling the metabolic disorders of human obesity in rodents
Roland Buettner et al.
OBESITY (2007)
Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy
Wenjing Zheng et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)
Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy
Elias J. Jeyarajah et al.
CLINICS IN LABORATORY MEDICINE (2006)
TLR4 links innate immunity and fatty acid-induced insulin resistance
Hang Shi et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Altered adipose and plasma sphingolipid metabolism in obesity - A potential mechanism for cardiovascular and metabolic risk
Fahumiya Samad et al.
DIABETES (2006)
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Takashi Kadowaki et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1
O Sukocheva et al.
JOURNAL OF CELL BIOLOGY (2006)
LC-MS-based method for the qualitative and quantitative analysis of complex lipid mixtures
U Sommer et al.
JOURNAL OF LIPID RESEARCH (2006)
Transforming Growth Factor β1 release by human adipose tissue is enhanced in obesity
JN Fain et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2005)
Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism
M Blüher et al.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2005)
TrkA-to-p75NTR molecular switch activates amyloid β-peptide generation during aging
C Costantini et al.
BIOCHEMICAL JOURNAL (2005)
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry
PK Salo et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2005)
S1P1-selective in vivo-active agonists from high-throughput screening:: Off-the-shelf chemical probes of receptor interactions, signaling, and fate
EJ Jo et al.
CHEMISTRY & BIOLOGY (2005)
Adipose tissue is a regulated source of interleukin-10
CE Juge-Aubry et al.
CYTOKINE (2005)
Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance
M Kabir et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)
Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1
M Otero et al.
ARTHRITIS RESEARCH & THERAPY (2005)
A new interface to couple thin-layer chromatography with laser desorption/atmospheric pressure chemical ionization mass spectrometry for plate scanning
S Peng et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2005)
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
RG Cutler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A simple device for the extraction of TLC spots: direct coupling with an electrospray mass spectrometer
H Luftmann
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2004)
Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
L Heilbronn et al.
INTERNATIONAL JOURNAL OF OBESITY (2004)
A high pressure matrix-assisted laser desorption ion source for Fourier transform mass spectrometry designed to accommodate large targets with diverse surfaces
PB O'Connor et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2004)
Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3
T Houjou et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2004)
Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability
KR Johnson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism
K Hanada
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2003)
The emergence of the metabolic syndrome with menopause
MC Carr
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation
JK Yun et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)
A central role for JNK in obesity and insulin resistance
J Hirosumi et al.
NATURE (2002)
Sphingomyelinases:: enzymology and membrane activity
FM Goñi et al.
FEBS LETTERS (2002)
Ceramide mediates insulin resistance by tumor necrosis factor-α in brown adipocytes by maintaining Akt in an inactive dephosphorylated state
T Teruel et al.
DIABETES (2001)
Toll-like receptors and innate immunity
R Medzhitov
NATURE REVIEWS IMMUNOLOGY (2001)
Sphingomyelin and ceramide as regulators of development and lifespan
RG Cutler et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2001)
Rac1 activity is required for the activation of hypoxia-inducible factor 1
K Hirota et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structural basis of molecular mimicry
KW Wucherpfennig
JOURNAL OF AUTOIMMUNITY (2001)
Role of membrane lipids in regulation of vulnerability to oxidative stress in PC12 cells: Implication for aging
NA Denisova et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
Childhood body composition in relation to body mass index
LM Maynard et al.
PEDIATRICS (2001)
Plasma sphingomyelin level as a risk factor for coronary artery disease
XC Jiang et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2000)
Application of liquid chromatography-nuclear magnetic resonance spectroscopy to the identification of natural products
SC Bobzin et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2000)
Ceramide as a second messenger: sticky solutions to sticky problems
K Venkataraman et al.
TRENDS IN CELL BIOLOGY (2000)
Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase
K Pahan et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women -: The health, risk factors, exercise training, and genetics (HERITAGE) family study
JP Després et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2000)
Plasminogen activator inhibitor 1, transforming growth factor-β1, and BMI are closely associated in human adipose tissue during morbid obesity
MC Alessi et al.
DIABETES (2000)
Effect of menopausal status on body composition and abdominal fat distribution
MJ Toth et al.
INTERNATIONAL JOURNAL OF OBESITY (2000)
Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections
HM van Beuningen et al.
OSTEOARTHRITIS AND CARTILAGE (2000)