期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/ijms20235819
关键词
nanoparticles; drug delivery system; tumor endothelial cells; anti-angiogenic therapy; nucleic acids
资金
- Ministry of Health, Labor andWelfare
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science KAKENHI [18K18351]
- JST CREST, Japan [JPMJCR17H1]
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Ichiro Kanehara Foundation
- Grants-in-Aid for Scientific Research [18K18351] Funding Source: KAKEN
Because angiogenesis is a major contributor to cancer progression and metastasis, it is an attractive target for cancer therapy. Although a diverse number of small compounds for anti-angiogenic therapy have been developed, severe adverse effects commonly occur, since small compounds can affect not only tumor endothelial cells (TECs), but also normal endothelial cells. This low selectivity for TECs has motivated researchers to develop alternate types of drug delivery systems (DDSs). In this review, we summarize the current state of knowledge concerning the delivery of nano DDSs to TECs. Their payloads range from small compounds to nucleic acids. Perspectives regarding new therapeutic targets are also mentioned.
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