期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms20215297
关键词
prolactin-releasing peptide; GPR10; RF-amide peptides; food intake regulation; energy expenditure; neuroprotection; signaling
资金
- Grant Agency of the Czech Republic [18-10591S]
- Academy of Sciences of the Czech Republic [RVO: 61388963]
Prolactin-releasing peptide (PrRP) belongs to the large RF-amide neuropeptide family with a conserved Arg-Phe-amide motif at the C-terminus. PrRP plays a main role in the regulation of food intake and energy expenditure. This review focuses not only on the physiological functions of PrRP, but also on its pharmacological properties and the actions of its G-protein coupled receptor, GPR10. Special attention is paid to structure-activity relationship studies on PrRP and its analogs as well as to their effect on different physiological functions, mainly their anorexigenic and neuroprotective features and the regulation of the cardiovascular system, pain, and stress. Additionally, the therapeutic potential of this peptide and its analogs is explored.
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