期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/ijms20205029
关键词
autophagy; alcohol-related liver disease; nuclear receptor; ncRNA; non-parenchymal cell
资金
- NIH [R01AA021751, R01DK116605]
Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been observed in ALD. Generally, autophagy is considered to protect the liver from alcohol-induced injury and steatosis. In this review, we will summarize novel modulators of autophagy in hepatic metabolism and ALD, including autophagy-mediating non-coding RNAs (ncRNAs), and crosstalk of autophagy machinery and nuclear factors. We will also discuss novel functions of autophagy in hepatocytes and non-parenchymal hepatic cells during the pathogenesis of ALD and other liver diseases.
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