期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 301, 期 -, 页码 207-214出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2019.11.004
关键词
Arginase; Endothelial dysfunction; Cardiovascular disease; Diabetes; Reactive oxygen species
资金
- Swedish Research Council [2016-01284]
- Swedish Heart-Lung Foundation [20160239]
- Stockholm County Council
- Diabetes Research and Wellness Foundation
- European Foundation for the Study of Diabetes
- Karolinska Institutet
- Swedish Research Council [2016-01284] Funding Source: Swedish Research Council
- Vinnova [2016-01284] Funding Source: Vinnova
- Formas [2016-01284] Funding Source: Formas
Endothelial dysfunction represents an early change in the vascular wall in areas prone to atherosclerotic plaque formation and is present in association with several risk factors for cardiovascular disease. The underlying mechanisms behind endothelial dysfunction are multifactorial and complex. Arginase has emerged as a key player in the regulation of endothelial integrity by the ability of reciprocally inhibits nitric oxide formation and promoting oxidative stress. A chain of evidence suggest that arginase is implicated in the pathogenesis underlying endothelial dysfunction induced by several cardiovascular risk factors and established cardiovascular disease including diabetes, hypercholesteremia, ischemia/reperfusion, atherosclerosis, obesity, ageing and hypertension. Recent data has unveiled a key role of arginase as one of the key mechanisms underlying endothelial dysfunction in diabetes and may serve as a potential therapeutic target in previously overlooked compartments including red blood cells. The current review is devoted to discuss arginase as a key mediator in endothelial dysfunction and the potential for therapeutic possibilities to target this enzyme in various diseases, especially type 2 diabetes, atherosclerosis and ischemia/reperfusion with focus on translational and clinical aspects. Moreover, approaches of how and in which patient group(s) arginase may be targeted in future clinical trials are discussed. (C) 2019 Elsevier B.V. All rights reserved.
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