期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 146, 期 -, 页码 1050-1059出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.09.230
关键词
Biopolymer; Hydrogel, gelatin; Silver nanopartides; Dopamine; Antibacterial activity; Enzymatic cross-linking
资金
- Ministry of Science and Technology, Taiwan [MOST 107-2923-M-006-002-MY3, 108-2221-E-006-034-MY3]
- Hierarchical Green-Energy Materials (Hi-GEM) Research Center, from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project, Ministry of Education (MOE)
- Ministry of Science and Technology [MOST 107-3017-F-006-003]
Hydrogels containing silver nanopartides (AgNPs) were recently found to exhibit excellent antibacterial properties against both gram-negative/positive bacteria and fungi. In this study, we reported the synthesis of AgNPs-contained gelatin-polyethylene glycol-dopamine (AgNP-GPD) hydrogels via the in situ formation of AgNPs in GPD polypeptide solution, followed by an enzymatic cross-linking reaction to form hydrogels. The experimental results showed that the reducing reaction exerted by GPD polypeptides under physiological conditions can afford the formation of AgNPs in situ in the polypeptide solution without the need for additional reducing agents and/or processes such as UV or thermal treatments and then the hydrogelation of GPD polypeptide solution containing AgNPs were preceeded via enzymatic cross-linking reaction. It was found that the gelation time, hydrogel mechanical property, degree of swelling and degree of enzymatic degradation for both GPD and AgNP-GPD hydrogels can be tuned by varying enzyme/oxidative agent concentration, catechol content, and reducing reaction conditions such as reaction time and silver ion concentration. Importantly, AgNP-GPD hydrogels exhibit excellent antibacterial properties against gram-negative and gram-positive bacteria. This type of hydrogel is a promising biomaterial for biomedical applications including wound healing and tissue engineering. (C) 2019 Elsevier B.V. All rights reserved.
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