Controlled release of vitamin B1 and evaluation of biodegradation studies of chitosan and gelatin based hydrogels

Thiamine, also known as vitamin B-1, is a vitamin synthesized for dietary supplementation and medication. In order to improve dissolution, bioavailability and sustained release of Thiamine, we prepared Thiamine hydrochloride (TH) and beta-cyclodextrin (beta-CD) host-guest solid inclusion complexes by microwave irradiation and studied the chemical characteristics and drug delivery potential of the complex. Based upon the molecular docking and phase solubility studies, we proposed the most probable structure of 1:1 inclusion complex. The value of the apparent stability constant was found to be 122.437 +/- 4 M-1. Furthermore, Chitosan-Gelatin hybrid polymer networks (HPNs) containing beta-CD: TH inclusion complexes (ICs) were synthesized and the drug release was studied. It was found that TH releases in a more controlled manner from the ICs compare to the directly loaded TH into the HPN. The continuous progress of biodegradation at different stages was tested through FTIR and SEM characterization, which showed HPNs synthesized are biodegradable and composting method was found to be more efficient than soil burial method. Overall, our study describes that microwave-induced synthesis of ICs is efficient, time-saving, and environment-friendly, and the ICs are useful for a controlled release of Vitamin Bl; thus, highlighting their potential in therapeutics of Vitamin B1 deficiency. (C) 2019 Elsevier B.V. All rights reserved.