期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 144, 期 -, 页码 1022-1033出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.09.179
关键词
Lachnum polysaccharide; Anti-tumor effect; Tumor-associated macrophages
资金
- National Natural Science Foundation of China [31470146]
- Anhui Natural Science Foundation [1808085QC66]
Therapeutic strategies that targeting tumor-associated macrophages (TAMs) reprogramming play a crucial role in ameliorating the immunosuppressive tumor microenvironment and boosting anti-tumor immune responses. In this study, we demonstrated that Lachnum polysaccharide (LEP) could work as an immunomodulator to reset TAMs from pro-tumor M2 to anti-tumor M1 phenotype. Mechanistically, LEP promoted Th1 polarization and the secretion of IFN-gamma, which played a key role in M1 phenotype polarization. In parallel, LEP might directly activate M1 macrophages via TLR4 mediated NE-kappa B signaling pathway. Moreover, LEP also resulted in the accumulation of anti-tumor immune cells and decreased the infiltration of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) and Treg cells, thereby potentiating anti-tumor immunity. In summary, these results revealed a novel mechanism of the anti-tumor effect of LEP and provided a potential new avenue targeting TAMs and cancer immunotherapy. (C) 2019 Published by Elsevier B.V.
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