期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 146, 期 -, 页码 922-930出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.09.215
关键词
Gellan gum; Alginate; Agarose; Hyaluronic acid; Cartilage
资金
- Bio & Medical Technology Development Program of the National Research Foundation (NRF) - Korean government (MSIPMOHW) [2017M3A9E4048318]
- National Research Foundation of Korea [2017M3A9E4048318] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Articular cartilage exhibits reduced self-healing following degeneration. This research evaluated the effects of hydrogels derived from various polysaccharides gellan gum (GG), alginate, and agarose on cartilage regeneration compared with that of hyaluronic acid (HA), which is commonly used in cartilage tissue engineering. Chondrocytes were isolated from the articular cartilage of New Zealand White (NZW) rabbits and stimulated with IL-1 beta followed by incubation with polysaccharides. The expressions of NF-kappa B and Cox-2 were decreased and those of I kappa B alpha, Sox-9, aggrecan, and type II collagen were increased in HA, GG, and Alginate groups. Osteochondral defects in NZW rabbits were treated with intra-articular polysaccharide injections; all except alginate resulted in tissue regeneration. Significant improvements were observed in cartilage regeneration in the GG and agarose groups. These results show that GG and agarose improve cartilage regeneration by suppressing inflammatory mediators and inducing cartilage formation and autophagy-related gene expression, indicating their potential for cartilage tissue engineering. (C) 2019 Elsevier B.V. All rights reserved.
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