期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 147, 期 -, 页码 1136-1145出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.10.082
关键词
Bacterial cellulose; Chitosan; Ciprofloxacin
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [PIP 0498]
- Universidad Nacional de La Plata [X701, I159]
- Agencia Nacional de Promocion Cientifica y Tecnica (ANPCyT) [PICT2016-4597]
Biopolymeric blends based on bacterial cellulose (BC) films modified with low molecular weight chitosan (Chi) were developed for controlled release of ciprofloxacin (Cip). Biophysical studies revealed a compatible and cooperative network between BC and Chi including deep structural changes in the BC matrix shown by spectroscopic and thermal analyses (SEM, roughness analysis, FTIR, XRD, TGA, mechanical properties and water vapor transmission rate). Incorporation of chitosan to BC matrix generated a thickening scaffold with high permeability to water vapor from 0.7 to 3.2 g mm/m(2) h. Cip loaded onto the BC-Chi film showed a hyperbolic release profile with a 30% decrease in antibiotic release mediated by the presence of Chi. BC-Chi blend films containing Cip tested against Pseudomonas aeruginosa and Staphylococcus aureus showed a synergic effect of chitosan on Cip antimicrobial activity. Besides, in vitro studies revealed the lack of cytotoxicity of BC-Chi-Cip films in human fibroblasts. (C) 2019 Elsevier B.V. All rights reserved.
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