期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 140, 期 -, 页码 973-984出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.08.198
关键词
Dictyophora indusiata polysaccharide; DSS-induced colitis; Intestinal barrier function; Macrophage polarization; Anti-inflammatory activity
资金
- National Natural Science Foundation of China [31700708]
- Natural Science Foundation of Jiangsu Province [BK20170181]
Polysaccharide (DIP) from Dictyophora indusiata has showed noteworthy anti-inflammatory activities. Given that the closely relationship between inflammation and ulcerative colitis, we speculated that DIP may alleviate ulcerative colitis. However, there was not any report about the effect of DIP on this disease. The purpose of this paper is to explore the protective effect and mechanism of DIP on DSS-induced colitis in C57BL/6 mice. The data indicated that DIP could improve DSS-induced colitis by restoring intestinal barrier function and regulating macrophage polarization. Its mechanism was found to be associated with decreased oxidative stresses and inflammation, suppressive key signal pathways related with colitis, improved the expression of tight junction proteins and downregulated M1 macrophage polarization. The results suggested that DIP could be served as an agent for improving intestinal inflammation in functional foods or nutraceutical formulations. (C) 2019 Elsevier B.V. All rights reserved.
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