4.5 Article

Microstructure visualization of conventional outflow pathway and finite element modeling analysis of trabecular meshwork

期刊

BIOMEDICAL ENGINEERING ONLINE
卷 15, 期 -, 页码 -

出版社

BIOMED CENTRAL LTD
DOI: 10.1186/s12938-016-0254-2

关键词

Conventional outflow pathway; Trans-scleral imaging method; 3D reconstruction; Porosity; Finite element modeling

资金

  1. National Natural Science Foundation of China [31570952]

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Background: The intraocular pressure (IOP) is maintained through a dynamic equilibrium between the production and drainage of aqueous humor. Elevation of intraocular pressure is mainly caused by the blocking of aqueous humor outflow pathway. Therefore, it is particularly important to study the structure of drainage pathway and the effect of ocular hypertension at the process of aqueous humor outflow. Methods: Conventional drainage pathway of aqueous humor, including trabecular meshwork (TM), Schlemm's canal (SC) and aqueous vein, were imaged by using transscleral imaging method with lateral resolution of 2 mu m. For quantitative assessment, the morphological parameters of the TM were measured with different IOP levels via a combination of measurements and simulations. Results: Images of the TM and the adjacent tissues were obtained. The porosity of TM with normal intraocular pressure varies from 0.63 to 0.74 as the depth increases, while in high IOP it is changed from 0.44 to 0.59. The diameter of aqueous vein varies from 32 to 43 mu m, and is smaller than that of SC, which varies from 48 to 64.67 mu m. Conclusions: Our research provides a non-contact method to visualize the microstructure of tissue for clinical examination associated with the blocking of the outflow pathway of aqueous humor in humans. The three-dimensional (3D) microstructures of limbus and the results of finite element modeling analysis of the TM model will serve for the future evaluation of new glaucoma surgical techniques.

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