期刊
BIOMEDICAL CHROMATOGRAPHY
卷 30, 期 11, 页码 1877-1881出版社
WILEY
DOI: 10.1002/bmc.3734
关键词
systemic lupus erythematosus; metabolomics; urine; GC; MS
类别
资金
- National Natural Science Foundation of China [81202601]
Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous organ and system manifestations. In this study, urinary metabolic alterations related to SLE were investigated by performing gas chromatography/mass spectrometry (GC/MS) based metabolomics and multivariate statistical analysis. Patients with SLE and healthy controls could be clearly differentiated in view of the metabolic abnormity in urine. Among 70 identified endogenous metabolites, 23 metabolites were dramatically increased in SLE patients, which involved in several key metabolic pathways including energy metabolism, nucleotide metabolism, oxidative stress and gut-microbiome-derived metabolism. This noninvasive and GC/MS-based metabolomic technique is a promising and potent strategy for identifying novel biomarkers and understanding pathogenesis of SLE. Copyright (c) 2016 John Wiley & Sons, Ltd.
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