What we say and what we mean when we say redundancy and robustness of the chemokine system - how CCR5 challenges these concepts

Classically, robustness and redundancy are features that define the intricate and connected functioning of the chemokine system. Following these ideas, the lack of a particular chemokine or chemokine receptor could be compensated by the presence of other molecules with similar functions, ensuring robustness to the systems. Although these concepts are generally accepted, they represent an oversimplification of a highly complex system that works in a context-dependent manner. Based on different studies, and taking as an example the chemokine receptor CCR5 (C-C chemokine receptor type 5) and the genetic variant CCR5 Delta 32, which on several occasions challenge the classical concepts of redundancy and robustness of the chemokine system, we will discuss and question this general and oversimplified point of view.