期刊
IMMUNOLOGY
卷 159, 期 1, 页码 15-25出版社
WILEY
DOI: 10.1111/imm.13149
关键词
layered immunity; mucosal immunology; neonatal window of opportunity; postnatal development
类别
资金
- German Research Foundation [TO 1052/1-1, HO 2236/14-1, HO 2236/11-1, CRC1382]
The intricate host-microbial interaction and the overwhelming complexity of the mucosal immune system in the adult host raise the question of how this system is initially established. Here, we propose the implementation of the concept of the 'postnatal window of opportunity' into the model of a 'layered immunity' to explain how the newborn's mucosal immune system matures and how host-microbial immune homeostasis is established after birth. We outline the concept of a timed succession of non-redundant phases during postnatal immune development and discuss the possible influence of external factors and conditions.
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