期刊
BIOMATERIALS
卷 97, 期 -, 页码 1-9出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.04.034
关键词
Nanoscale metal-organic framework; Photodynamic therapy; Radiation therapy; Combination therapy
资金
- National Basic Research Programs of China (973 Program) [2012CB932600]
- National Natural Science Foundation of China [51525203, 51132006]
- Jiangsu Natural Science Fund for Distinguished Young Scholars [BK20130005]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
Nanoscale metal organic frameworks (NMOFs) have shown great potential in biomedicine owing to their structural/chemical diversities, high molecular loading capacities, and intrinsic biodegradability. Herein, we report the rational design of a NMOF composed by hafnium (Hf4+) and tetrakis (4-carboxyphenyl) porphyrin (TCPP). In such Hf-TCPP NMOFs, while TCPP is a photosensitizer to allow photodynamic therapy (PDT), Hf4+ with strong X-ray attenuation ability could serve as a radio-sensitizer to enhance radiotherapy (RT). Those NMOFs with polyethylene glycol (PEG) coating show efficient tumor homing upon intravenous injection, and thus could be used for in vivo combined RT & PDT, achieving a remarkable anti-tumor effect. Importantly, Hf-TCPP NMOFs show efficient clearance from the mouse body, minimizing concerns regarding their possible long-term toxicity. Our work thus presents a new concept of developing multifunctional NMOFs as a biodegradable carrier-free system, in which both metal ions and organic ligands are fully utilized to exert their therapeutic functions. (C) 2016 Elsevier Ltd. All rights reserved.
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