期刊
BIOMATERIALS
卷 100, 期 -, 页码 118-133出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.05.030
关键词
Magnetic mesoporous silica; Janus; Magnetic targeting; Liver cancer; Chemotherapy; Low systemic toxicity
资金
- National Natural Science Foundation of China [81071886, 81201804, 81371681]
- Science and Technology Support Program of Jilin province [20090441, 201205006]
- Science and Technology Department of Suzhou City [ZXY201434]
- National Research Foundation for the Doctoral Program of Higher Education of China [20120061120079]
- State Key Laboratory of Supramolecular Structure and Materials of Jilin University [SKLSSM 201504, SKLSSM 201317]
Tumor-targeted delivery of anti-cancer drugs with controlled drug release function has been recognized as a promising strategy for pursuit of increased chemotherapeutic efficacy and reduced adverse effects. Development of magnetic nanoparticulates as delivery carriers to accommodate cytotoxic drugs for liver cancer treatment has evoked immense interest with respect to their convenience in biomedical application. Herein, we engineered multifunctional Janus nanocomposites, characterized by a head of magnetic Fe3O4 and a body of mesoporous SiO2 containing doxorubicin (DOX) as nano-bullets (M-MSNs-DOX). This nanodrug formulation possessed nanosize with controlled aspect-ratio, defined abundance in pore structures, and superior magnetic properties. M-MSN-DOX was determined to induce selective growth inhibition to the cancer cell under magnetic field rather than human normal cells due to its preferable endocytosis by the tumor cells and pH-promoted DOX release in the interior of cancer cells. Ultimately, both subcutaneous and orthotropic liver tumor models in mice have demonstrated that the proposed Janus nano-bullets imposed remarkable suppression of the tumor growth and significantly reduced systematic toxicity. Taken together, this study demonstrates an intriguing targeting strategy for liver cancer treatment based on a novel Janus nano-bullet, aiming for utilization of nanotechnology to obtain safe and efficient treatment of liver cancer. (C) 2016 Elsevier Ltd. All rights reserved.
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