期刊
BIOMATERIALS
卷 106, 期 -, 页码 119-133出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.08.016
关键词
Photothermal therapy; Photodynamic therapy; Chemotherapy; Micelle; Cancer therapy
资金
- National Science Fund for Distinguished Young Scholars [NSFC31525009]
- Sichuan Innovative Research Team Program for Young Scientists [2016TD0004]
- Distinguished Young Scholars of Sichuan University [2011SCU04B18]
Patients suffering from cancer have benefited from combination therapy. Nanocarriers are the ideal candidates for combination therapy. In this study, we constructed docetaxel (DTX) loaded micellar nanomedicines co-loaded with near infrared (NIR) dye-IR820 for photothermal therapy (PTT)/photodynamic therapy (PDT)/chemotherapy of breast cancer. Lyp-1, a tumor homing peptide, was introduced into the nanosystems to construct the active targeting nanomedicine. In order to deliver IR820 to the tumor site and overcome its short lifetime in vivo, a PEI derivative-PCL-g-PEI was introduced. IR820 with negative charge was formed stable static interaction with the amine groups, meanwhile, the absorption of IR820 in the NIR region was weakened. It indicated that the nanosystem constructed in this study may provide an alternative candidate for mild PIT. By the evaluation of the photothermal conversion in vivo, we can confirm that IR820 has been successfully delivered and effectively accumulated in the tumor site. Furthermore, the tumor cells targeting and anticancer performances of this nanosystem have been studied in vitro and in vivo. The results demonstrated Lyp-1 modification has enhanced the tumor targeting delivery of DTX and IR820. By combining PIT and PDT, DTX nanomedicine efficiently inhibited the growth and metastasis of breast cancer in mice. This nanosystem is a promising candidate for combination therapy of breast cancer. (C) 2016 Elsevier Ltd. All rights reserved.
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