期刊
BIOMATERIALS
卷 91, 期 -, 页码 90-127出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.03.019
关键词
PMOs; Mesoporous nanoparticles; Biocompatible properties; Advanced nanocarriers; Bioimaging; Therapeutic agent delivery
资金
- National Natural Science Foundation of China [21501009, 21127007]
- High-Level Talent Introduction Plan of University of Science & Technology Beijing [06500017]
- Fundamental Research Funds for the Central Universities [FRF-TP-15-019A1]
- Australian Research Council (ARC) [DP130104459, DP140104062]
- Natural Sciences and Engineering Research Council of Canada (NSERC)
Mesoporous silica material with organo-bridged silsesquioxane frameworks is a kind of synergistic combination of inorganic silica, mesopores and organics, resulting in some novel or enhanced physicochemical and biocompatible properties compared with conventional mesoporous silica materials with pure Si-O composition. With the rapid development of nanotechnology, monodispersed nanoscale periodic mesoporous organosilica nanoparticles (PMO NPs) and organo-bridged mesoporous silica nano particles (MSNs) with various organic groups and structures have recently been synthesized from 100%, or less, bridged organosilica precursors, respectively. Since then, these materials have been employed as carrier platforms to construct bioimaging and/or therapeutic agent delivery nanosystems for nano biomedical application, and they demonstrate some unique and/or enhanced properties and performances. This review article provides a comprehensive overview of the controlled synthesis of PMO NPs and organ-bridged MSNs, physicochemical and biocompatible properties, and their nano-biomedical application as bioimaging agent and/or therapeutic agent delivery system. (c) 2016 Elsevier Ltd. All rights reserved.
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