期刊
BIOMATERIALS
卷 103, 期 -, 页码 116-127出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.06.037
关键词
808 nm-excited upconversion nanoprobes; Low heating effect; High-efficacy photodynamic therapy; HER2-overexpressed breast cancer
资金
- National Key Basic Research Program of China [2014CB744504]
- National Natural Science Foundation of China [U1332117, U1432114, 31470961]
- Special Program for Applied Research on Super Computation of the NSFC-Guangdong Province Joint Project on National Supercomputer Centre in Guangzhou (NSCC-GZ)
- Science & Technology Department of Zhejiang Province [2015C31027]
- Science & Technology Bureau of Ningbo City [2015C50004, 2015B11002]
- Chinese Academy of Sciences [KGZD-EW-T06]
- Postdoctoral Science Foundation of China [2014M562577]
To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO(2)) with low heating effect and deep penetration has been successfully constructed for targeted upconversion luminescence, magnetic resonance imaging (MRI) and high-efficacy PDT in HER2-overexpressed breast cancer. In this nanocomposite, photosensitizers (Ce6) were covalently conjugated inside of mesoporous silica to enhance the PDT efficacy by shortening the distance of fluorescence resonance energy transfer and to decrease the cytotoxicity by preventing the undesired leakage of Ce6. Compared with UCNPs@mSiO(2)@Ce6, UCNPs@Ce6@mSiO(2) greatly promoted the singlet oxygen generation and amplified the PDT efficacy under the excitation of 808 nm laser. Importantly, the designed nanoprobe can greatly improve the uptake of HER2-positive cells and tumors by modifying the site-specific peptide, and the in vivo experiments showed excellent MRI and PDT via intravenous injection by modeling MDA-MB-435 tumor-bearing nude mice. Our strategy may provide an effective solution for overcoming the heating effect and improving the PDT efficacy of upconversion nanoprobes, and has potential application in visualized theranostics of HER2-overexpressed breast cancer. (C) 2016 Elsevier Ltd. All rights reserved.
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