期刊
BIOMATERIALS
卷 89, 期 -, 页码 56-66出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.02.025
关键词
Microparticles; Oncolytic adenovirus; Delivery system; Cancer therapy
资金
- National Basic Research Program of China [2014CB542100]
- National Science Fund for Distinguished Young Scholars of China [81225021]
- National Natural Science Foundation of China [81172162, 81472653, 81472735, 81530080]
- Special Fund of Health Public Welfare Profession of China [201302018]
- Soundny (Sheng-Qi-An) Biotech (Wuhan, China)
Oncolytic viruses have been utilized for the treatment of various cancers. However, delivery of the viral particles to tumor cells remains a major challenge. Microparticles (MP) are vesicle forms of plasma membrane fragments of 0.1-1 mu m in size that are shed by cells. We have previously shown the delivery of chemotherapeutic drugs using tumor cell-derived MPs (T-MP). Here we report that T-MPs can be utilized as a unique carrier system to deliver oncolytic adenoviruses to human tumors, leading to highly efficient cytolysis of tumor cells needed for in vivo treatment efficacy. This T-MP-mediated oncolytic virotherapy approach holds multiple advantages, including: 1) delivery of oncolytic adenovirus by T-MPs is able to avoid the antiviral effect of host antibodies; 2) delivery of oncolytic adenovirus by T-MPs is not limited by virus-specific receptor that mediates the entry of virus into tumor cells; 3) T-MPs are apt at delivering oncolytic adenoviruses to the nucleus of tumor cells as well as to stem-like tumor-repopulating cells for the desired purpose of killing them. These findings highlight a novel oncolytic adenovirus delivery system with highly promising clinical applications. (C) 2016 Elsevier Ltd. All rights reserved.
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