期刊
BIOMATERIALS
卷 82, 期 -, 页码 84-93出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.12.010
关键词
Graphene; Biocompatibility; Brain; Neurogenesis; Neurons; Astrocytes
资金
- European Union [NMP3-LA-2008-213277]
- Spanish Ministerio de Economia y Competitividad (MINECO) [CIBERNED CB06/05/0065, SAF2013-47596R, CSIC 201220E098]
- Spanish Ministry of Science and Innovation (MiCInn) [MAT 2010-18749]
- MINECO [SAF2010-15173, BFU2011-26339]
- INCRECyT project from European Social Fund
- PCyTA
- JCCM
Graphene and graphene-based nanomaterials (GBNs) are being investigated as potential substrates for the growth of neural stem cells (NSCs), neurons and glia in cell culture models. In contrast, reports testing the effects of graphene directly with adult neural cells in vivo are missing. Here we studied the biocompatibility of thermally reduced graphene (TRG) with neurons and glia, as well as with the generation of new neurons in the adult brain in vivo. TRG injected in the brain together with a retroviral vector expressing GFP to label dividing progenitor cells in the core of the adult olfactory bulb (OB) did not alter de novo neurogenesis, neuronal and astrocyte survival nor did it produce a microglial response. These findings indicate that TRG may be a biocompatible material with neuronal and glial cells in vivo and support its use in studies of brain repair and function. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据