期刊
BIOMATERIALS
卷 83, 期 -, 页码 363-382出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.01.024
关键词
Skeletal stem cell; Osteogenesis; Angiogenesis; Tissue regeneration; Bone tissue engineering; Biofabrication
资金
- BBSRC [BB/L021072/1, BB/L00609X/1]
- BBSRC (BBSRC-Ministry of Science and Technology, Taiwan)
- MRC [G1000842, G0802397]
- EU FP7 [318553]
- Ministry of Science and Technology, Taiwan [MOST 103-2218-E-038-002, MOST 103-2911-I-038-503, MOST 103-2314-B-038-038]
- Ministry of Health and Welfare, Taiwan [MOHW 104-TDU-M-112-000003]
- [MK/KO26682/1]
- Biotechnology and Biological Sciences Research Council [BB/L00609X/1, BB/L026384/1, BB/L021072/1] Funding Source: researchfish
- Medical Research Council [G0802397, G1000842] Funding Source: researchfish
- BBSRC [BB/L026384/1, BB/L021072/1, BB/L00609X/1] Funding Source: UKRI
- MRC [G1000842, G0802397] Funding Source: UKRI
The rising incidence of bone disorders has resulted in the need for more effective therapies to meet this demand, exacerbated by an increasing ageing population. Bone tissue engineering is seen as a means of developing alternatives to conventional bone grafts for repairing or reconstructing bone defects by combining biomaterials, cells and signalling factors. However, skeletal tissue engineering has not yet achieved full translation into clinical practice as a consequence of several challenges. The use of additive manufacturing techniques for bone biofabrication is seen as a potential solution, with its inherent capability for reproducibility, accuracy and customisation of scaffolds as well as cell and signalling factor delivery. This review highlights the current research in bone biofabrication, the necessary factors for successful bone biofabrication, in addition to the current limitations affecting biofabrication, some of which are a consequence of the limitations of the additive manufacturing technology itself. (C) 2016 Elsevier Ltd. All rights reserved.
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