期刊
BIOMATERIALS
卷 104, 期 -, 页码 201-212出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.06.046
关键词
Boron neutron capture therapy; Drug delivery system; Boron cluster-containing redox nanoparticles; ROS scavenging; Adverse effect suppression
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) [25220203]
- Grants-in-Aid for Scientific Research [26460718] Funding Source: KAKEN
A boron delivery system with high therapeutic efficiency and low adverse effects is crucial for a successful boron neutron capture therapy (BNCT). In this study, we developed boron cluster-containing redox nanoparticles (BNPs) via polyion complex (PIC) formation, using a newly synthesized poly(-ethylene glycol)-polyanion (PEG-polyanion, possessing a B-10-enriched boron cluster as a side chain of one of its segments) and PEG-polycation (possessing a reactive oxygen species (ROS) scavenger as a side chain of one of its segments). The BNPs exhibited high colloidal stability, selective uptake in tumor cells, specific accumulation, and long retention in tumor tissue and ROS scavenging ability. After thermal neutron irradiation, significant suppression of tumor growth was observed in the BNP-treated group, with only 5-ppm B-10 in tumor tissues, whereas at least 20-ppm B-10 is generally required for low molecular weight (LMW) B-10 agents. In addition, increased leukocyte levels were observed in the LMW B-10 agent-treated group after thermal neutron irradiation, and not in BNP-treated group, which might be attributed to its ROS scavenging ability. No visual metastasis of tumor cells to other organs was observed 1 month after irradiation in the BNP-treated group. These results suggest that BNPs are promising for enhancing the BNCT performance. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据