期刊
BIOMATERIALS
卷 103, 期 -, 页码 170-182出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.06.042
关键词
Cardiovascular stent; Biomimetic surface pattern; Re-endothelialization; Femtosecond laser
资金
- National Natural Science Foundation of China [51201056, 51171058, 51401146]
- Natural Science Foundation of Hebei Province of China [E2013202021, E2013202022, E2015202037]
- Outstanding Youth Foundation of Hebei Province of China [E2015202282]
- Science and Technology Correspondent Project of Tianjin [14JCTPJC00496, 15JCYBJC29900]
- Danish Natural Science Research Councils
- Strategic Growth Technologies Innovation Fund Denmark [0603-00439B]
- Karen Elise Jensens Fond
- AUFF NOVA project
The use of cardiovascular stents for rapid in vivo re-endothelialization is a promising strategy for reducing cardiovascular implantation or preventing local thrombus formation and restenosis. Surface-patterned intravascular endoprosthetic stents have been developed to prevent life-threatening complications. In this study, vascular smooth muscle cell (VSMC)-biomimetic surface patterns were fabricated on 316L cardiovascular stents using a femtosecond laser and then implanted into the iliac artery of rabbit. The in vitro data revealed that the bionic surface patterns matched the morphology of the VSMCs well, which promotes the adhesion, proliferation, and migration of human umbilical vein endothelial cells. In addition, the patterned surfaces can significantly enhance re-endothelialization. Consequently, the surface biomimetic stent with the VSMC surface pattern is likely an effective approach to ensure rapid re-endothelialization and possibly reduce the incidence of in-stent restenosis. (C) 2016 Elsevier Ltd. All rights reserved.
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