期刊
BIOMATERIALS
卷 106, 期 -, 页码 286-294出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.08.035
关键词
Calcium phosphate; Chimeric dengue virus; Biomineralization; Nanohybrid; Needle-free delivery
资金
- National Natural Science Foundation of China [21201150, 31270974, 21571155]
- National Basic Research Project of China [2012CB518904]
- National Key Research and Development Project of China [2016YFD0500304]
- Fundamental Research Funds for the Central Universities [2016QN81020]
- National Excellent Young Scientist Foundation of NSFC [81522025]
- Academy of Medical Sciences, UK
- NSFC of China [81661130162]
Frequent outbreaks and the rapid global spread of infectious diseases have increased the urgent need for massive vaccination especially in countries with limited resources. Intranasal vaccination facilitates the mass vaccination via needle-free delivery of vaccine through nasal mucosal surfaces. Inspired by the strong capability of calcium phosphate (CaP) materials to adhere to cells and tissues, we propose to improve nasal vaccination by using a biomineralization-based strategy. The vaccine nanohybrid was obtained by covering the viral surface with CaP nanoshell, which changed the physiochemical properties of original vaccine, resulting in the increase of mucosal adhesion to the nasal tissues. The core-shell structure was beneficial for the receptor-independent uptake and the induction of elevated local IgA response within the nasal cavity. Moreover, the vaccine complex elicited enhanced systemic antibody response that neutralized wild type of dengue virus and promoted the systemic cellular immune responses. This achievement presents the potential of CaP based vaccine biomineralization for the fabrication of needle-free vaccine formulation. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据