期刊
BIOMATERIALS
卷 85, 期 -, 页码 54-64出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.01.053
关键词
FePt nanoparticle; Infrared-active; Multi-modality contrast; Multiphoton luminescence; Photoacoustic responses; Molecular imaging
资金
- Ministry of Science and Technology of Taiwan, National Health Research Institute of Taiwan (NHRI) [NHRI-EX103-10137EI]
- Molecular Imaging Center, National Taiwan University
A single nanomaterial with multiple imaging contrasts and functions is highly desired for multiscale theragnosis. Herein, we demonstrate single 1-1.9 mu m infrared-active FePt alloy nanoparticles (FePt NPs) offering unprecedented four-contrast-in-one molecular imaging computed tomography (CT), magnetic resonance imaging (MRI), photoacoustic (PA) imaging, and high-order multiphoton luminescence (HOMPL) microscopy. The PA response of FePt NPs outperforms that of infrared-active gold nanorods by 3- to 5.6-fold under identical excitation fluence and particle concentrations. HOMPL (680 nm) of an isolated FePt NP renders spatial full-width-at-half-maximum values of 432 nm and 300 nm beyond the optical diffraction limit for 1230-nm and 920-nm excitation, respectively. The in vivo targeting function was successfully visualized using HOMPL, PA imaging, CT, and MRI, thereby validating FePt as a single nanomaterial system covering up to four types (Optical/PA/CT/MRI) of molecular imaging contrast, ranging from the microscopic level to whole-body scale investigation. (C) 2016 Elsevier Ltd. All rights reserved.
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