期刊
HEART
卷 106, 期 9, 页码 691-697出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/heartjnl-2019-315485
关键词
Translational cardiovascular science; Epidemiology; Coronary artery disease
资金
- Crafoordska Stiftelsen
- Vetenskapsradet
- Novo Nordisk
- Ake Wiberg Stiftelse
- Goran Gustafssons Stiftelse for Naturvetenskaplig och Medicinsk Forskning
- Knut och Alice Wallenbergs Stiftelse
- Kungliga Fysiografiska Sallskapet i Lund
- Ernhold Lundstrom Research Foundation
- Region Skane
- Skane University Hospital
- European Foundation for the Study of Diabetes [EFSD 2015/338]
- Hjart--L ungfonden
- H2020 European Research Council
- Diabetesfonden
- Direktor Albert Pahlssons Stiftelse
- Knut and Alice Wallenberg Foundation
- Goran Gustafsson Foundation
- Swedish Heart and Lung Foundation
- Swedish Research Council
- Novo Nordisk Foundation
- Albert Pahlsson Research Foundation
- Crafoord Research Foundation
- Royal Physiographic Society of Lund
- Ake Wiberg Foundation
- European Research Council [649021]
- Swedish Diabetes Foundation
- European Foundation for Study of Diabetes [EFSD 2015/338]
Objectives We recently identified a health conscious food pattern (HCFP) associated with reduced risk of cardiometabolic disease. However, the molecular events linking the healthy food pattern to reduced risk of cardiometabolic disease are unknown. Our aim was to identify plasma metabolites associated with the HCFP and test if such metabolites predict cardiometabolic disease and mortality. Methods Using liquid-chromatography mass-spectrometry, 112 plasma metabolites were measured in 3236 participants without cardiovascular disease (CVD) and diabetes mellitus from the population-based Malmo Diet and Cancer study. Metabolites associated with the HCFP were identified using multivariable adjusted linear regressions followed by Bonferroni correction. The healthy dietary biomarkers were subsequently related to risk of cardiometabolic disease and mortality during long-term follow-up with multivariable adjusted Cox proportional hazards models. Results During a median follow-up time of 21.4 years, 603 participants developed CVD, 362 developed diabetes mellitus and 843 participants died. Five healthy dietary biomarkers were associated with the HCFP at baseline (p<0.0004) and four predicted at least one of the studied end points (p<0.05). Ergothioneine was the metabolite most strongly connected to the HCFP and was associated with a lower risk of coronary disease (HR per 1 SD increment of ergothioneine, HR=0.85, p=0.01), cardiovascular mortality (HR=0.79, p=0.002) and overall mortality (HR=0.86, p=4e-5). Conclusions We identified that higher ergothioneine was an independent marker of lower risk of cardiometabolic disease and mortality, which potentially can be induced by a specific healthy dietary intake.
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