期刊
GLIA
卷 68, 期 3, 页码 670-679出版社
WILEY
DOI: 10.1002/glia.23749
关键词
lncRNA; migration; peripheral nerve injury; Schwann cell; Vimentin
资金
- National Major Project of Research and Development [2017YFA0104701]
- National Natural Science Foundation of China [31500823, 31371062]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Schwann cell, the major glial cell in the peripheral nervous system, plays an essential role in peripheral nerve regeneration. However, the regulation of Schwann cell behavior following nerve injury is insufficiently explored. According to the development of high-throughput techniques, long noncoding RNAs (lncRNAs) have been recognized. Accumulating evidence shows that lncRNAs take part in diverse biological processes and diseases. Here, by microarray analysis, we identified an upregulated lncRNA profile following sciatic nerve injury and focused on BC088259 for further investigation. Silencing or overexpression of BC088259 could affect Schwann cell migration. Mechanistically, BC088259 might exert this regulatory role by directly binding with Vimentin. Collectively, our study not only revealed a set of upregulated lncRNAs following nerve injury but also identified a new functional lncRNA, BC088259, which was important for Schwann cell migration, providing a therapeutic avenue toward peripheral nerve injury.
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