相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia
Craig T. Wallington-Beddoe et al.
BRITISH JOURNAL OF HAEMATOLOGY (2019)
Genetics and mechanisms of NT5C2-driven chemotherapy resistance in relapsed ALL
Chelsea L. Dieck et al.
BLOOD (2019)
Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
Laura Hinze et al.
CANCER CELL (2019)
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
Sven Christian et al.
LEUKEMIA (2019)
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
Paolo Gallipoli et al.
BLOOD (2018)
B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
Gang Xiao et al.
CELL (2018)
Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia
Mark A. Gregory et al.
EXPERIMENTAL HEMATOLOGY (2018)
Report of the relapsed/refractory cohort of SWOG S0919: A phase 2 study of idarubicin and cytarabine in combination with pravastatin for acute myelogenous leukemia (AML)
Anjali S. Advani et al.
LEUKEMIA RESEARCH (2018)
Clonal evolution mechanisms in NT5C2 mutant/relapsed acute lymphoblastic leukaemia
Gannie Tzoneva et al.
NATURE (2018)
Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
C. D. DiNardo et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Statins enhance efficacy of venetoclax in blood cancers
J. Scott Lee et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Forodesine in the treatment of relapsed/refractory peripheral T-cell lymphoma: an evidence-based review
Shinichi Makita et al.
ONCOTARGETS AND THERAPY (2018)
Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia
Jacqueline Lehmann-Che et al.
NATURE COMMUNICATIONS (2018)
Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells
Haobin Ye et al.
CANCER CELL (2018)
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Benjamin D. Hopkins et al.
NATURE (2018)
Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia
Daniel A. Pollyea et al.
NATURE MEDICINE (2018)
Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia
Jason A. Powell et al.
BLOOD (2017)
The Association of Dyslipidemia With Chronic Lymphocytic Leukemia: A Population-Based Study
Lee Mozessohn et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
Shiro L. Cramer et al.
NATURE MEDICINE (2017)
The Association of Dyslipidemia With Chronic Lymphocytic Leukemia: A Population-Based Study
Lee Mozessohn et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)
Genomics of Acute Myeloid Leukemia Diagnosis and Pathways
Lars Bullinger et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition
H-Q Ju et al.
LEUKEMIA (2017)
High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells
L. Poulain et al.
LEUKEMIA (2017)
Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia
Ayuna Hattori et al.
NATURE (2017)
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Simon Raffel et al.
NATURE (2017)
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Elodie M. Kuntz et al.
NATURE MEDICINE (2017)
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
Nina Fenouille et al.
NATURE MEDICINE (2017)
Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Thomas Farge et al.
CANCER DISCOVERY (2017)
Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase
Yong Yi et al.
JOURNAL OF CANCER (2017)
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
Luisa Cimmino et al.
CELL (2017)
Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia
Eytan M. Stein et al.
BLOOD (2017)
Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells
Yoko Tabe et al.
CANCER RESEARCH (2017)
Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of L-asparaginase in childhood ALL cells
I. Hermanova et al.
LEUKEMIA (2016)
A link between hypercholesterolemia and chronic lymphocytic leukemia
Signy Chow et al.
LEUKEMIA & LYMPHOMA (2016)
Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML
Mohammed Dany et al.
BLOOD (2016)
Review: Aberrant EVI1 expression in acute myeloid leukaemia
Adil A. Hinai et al.
BRITISH JOURNAL OF HAEMATOLOGY (2016)
Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation
Amin Huang et al.
CANCER LETTERS (2016)
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
David B. Sykes et al.
CELL (2016)
Metabolic Heterogeneity in Human Lung Tumors
Christopher T. Hensley et al.
CELL (2016)
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival
Rigel J. Kishton et al.
CELL METABOLISM (2016)
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
Natalie J. German et al.
MOLECULAR CELL (2016)
Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline
P-P Liu et al.
ONCOGENE (2016)
Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia
Koichi Oshima et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes
Polina Matre et al.
ONCOTARGET (2016)
SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation
Shuang-Nian Xu et al.
SCIENTIFIC REPORTS (2016)
The genetics and mechanisms of T cell acute lymphoblastic leukaemia
Laura Belver et al.
NATURE REVIEWS CANCER (2016)
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target
Francis Mussai et al.
BLOOD (2015)
Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias
Maria Rosaria Ricciardi et al.
BLOOD (2015)
Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition
Nathalie Jacque et al.
BLOOD (2015)
Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia
Alicia Cole et al.
CANCER CELL (2015)
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
Kivanc Birsoy et al.
CELL (2015)
AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow
Yusuke Saito et al.
CELL STEM CELL (2015)
Antileukemic Activity of 2-Deoxy-D-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with FLT3-ITD or c-KIT Mutations
Clement Larrue et al.
MOLECULAR CANCER THERAPEUTICS (2015)
Metabolic pathways promoting cancer cell survival and growth
Lindsey K. Boroughs et al.
NATURE CELL BIOLOGY (2015)
The genomic landscape of juvenile myelomonocytic leukemia
Elliot Stieglitz et al.
NATURE GENETICS (2015)
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
Daniel Herranz et al.
NATURE MEDICINE (2015)
Genomics in acute lymphoblastic leukaemia: insights and treatment implications
Kathryn G. Roberts et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2015)
Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming
Veronica Martinez-Marignac et al.
Oncotarget (2015)
Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis
Ying-Hua Wang et al.
CELL (2014)
Intravenous Vitamin C and Cancer: A Systematic Review
Heidi Fritz et al.
INTEGRATIVE CANCER THERAPIES (2014)
A NOTCH 1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia
Daniel Herranz et al.
NATURE MEDICINE (2014)
Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis
T. Liu et al.
CELL DEATH & DISEASE (2014)
Assessment of the effect of sphingosine kinase inhibitors on apoptosis, unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics
Cecilia Evangelisti et al.
ONCOTARGET (2014)
BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins
Levi J. Beverly et al.
BIOCHEMICAL JOURNAL (2013)
Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
Francis Mussai et al.
BLOOD (2013)
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
Lise Willems et al.
BLOOD (2013)
The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells
Celia Rosilio et al.
CANCER LETTERS (2013)
Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance
Costas A. Lyssiotis et al.
CELL CYCLE (2013)
BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
Eleni D. Lagadinou et al.
CELL STEM CELL (2013)
Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia
K. Morrow et al.
LEUKEMIA (2013)
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso et al.
NATURE (2013)
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Jaekyoung Son et al.
NATURE (2013)
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia
Julia A. Meyer et al.
NATURE GENETICS (2013)
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL
Gannie Tzoneva et al.
NATURE MEDICINE (2013)
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
Michael Pourdehnada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Haoqiang Ying et al.
CELL (2012)
Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells
Jingxuan Pan et al.
CELL CYCLE (2012)
Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo
Isaac Marin-Valencia et al.
CELL METABOLISM (2012)
AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications
C. Grimaldi et al.
LEUKEMIA (2012)
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
Wan Zhang et al.
NATURE CELL BIOLOGY (2012)
Antileukemic effects of AMPK activators on BCR-ABL-expressing cells
Eliza Vakana et al.
BLOOD (2011)
In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia
Irene Homminga et al.
BLOOD (2011)
The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
Claire L. Green et al.
BLOOD (2011)
Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia
Marko Skrtic et al.
CANCER CELL (2011)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu et al.
CANCER CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
Yu Li et al.
CELL METABOLISM (2011)
Pancreatic cancers require autophagy for tumor growth
Shenghong Yang et al.
GENES & DEVELOPMENT (2011)
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Jessie Yanxiang Guo et al.
GENES & DEVELOPMENT (2011)
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
Rebecca Lock et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Johannes Zuber et al.
NATURE (2011)
IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
Susanne Schnittger et al.
BLOOD (2010)
Pegylated arginase I: a potential therapeutic approach in T-ALL
Claudia P. Hernandez et al.
BLOOD (2010)
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
Alexa S. Green et al.
BLOOD (2010)
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Patrick S. Ward et al.
CANCER CELL (2010)
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Maria E. Figueroa et al.
CANCER CELL (2010)
Myc-dependent Mitochondrial Generation of Acetyl-CoA Contributes to Fatty Acid Biosynthesis and Histone Acetylation during Cell Cycle Entry
Fionnuala Morrish et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
Ismael Samudio et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Frank Weinberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
IDH2 Mutations in Patients with D-2-Hydroxyglutaric Aciduria
Martijn Kranendijk et al.
SCIENCE (2010)
Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells
Esther Hulleman et al.
BLOOD (2009)
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
Omar Abdel-Wahab et al.
BLOOD (2009)
Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia
Jerome Tamburini et al.
BLOOD (2009)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
NATURE (2009)
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Ping Gao et al.
NATURE (2009)
Mutation in TET2 in Myeloid Cancers
Francois Delhommeau et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
Elaine R. Mardis et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
IDH1 and IDH2 Mutations in Gliomas
Hai Yan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani et al.
SCIENCE (2009)
Global Regulation of Nucleotide Biosynthetic Genes by c-Myc
Yen-Chun Liu et al.
PLOS ONE (2008)
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The crystal structure of a mammalian fatty acid synthase
Timm Maier et al.
SCIENCE (2008)
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Ralph J. DeBerardinis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Teresa Palomero et al.
NATURE MEDICINE (2007)
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
Huafeng Zhang et al.
CANCER CELL (2007)
Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AME by the addition of pravastatin to idarubicin plus high-dose Ara-C: a phase 1 study
Steven M. Kornblau et al.
BLOOD (2007)
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
Teresa Palomero et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Altered glucose metabolism in childhood pre-B acute lymphoblastic leukaemia
J. M. Boag et al.
LEUKEMIA (2006)
Histone demethylation by a family of JmjC domain-containing proteins
Y Tsukada et al.
NATURE (2006)
Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
RH Xu et al.
LEUKEMIA (2005)
Arginine deprivation and metabolomics: Important aspects of intermediary metabolism in relation to the differential sensitivity of normal and tumour cells
DN Wheatley
SEMINARS IN CANCER BIOLOGY (2005)
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
F Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells
P Cafforio et al.
CARCINOGENESIS (2005)
Glutathione metabolism and its implications for health
GY Wu et al.
JOURNAL OF NUTRITION (2004)
Live-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity
B Stiles et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis
JH Wu et al.
CANCER RESEARCH (2004)
Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment
A Holleman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Survival of acute myeloid leukemia cells requires PI3 kinase activation
Q Xu et al.
BLOOD (2003)
The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase
AS Marsin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents
VL Schramm
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2002)
HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis
WWL Wong et al.
LEUKEMIA (2002)
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells
Z Xia et al.
LEUKEMIA (2001)
Lovastatin induces a pronounced differentiation response in acute myeloid leukemias
J Dimitroulakos et al.
LEUKEMIA & LYMPHOMA (2000)
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
AS Marsin et al.
CURRENT BIOLOGY (2000)
Accelerated publication -: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
RC Osthus et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)