期刊
BIOMARKERS IN MEDICINE
卷 10, 期 11, 页码 1153-1166出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2016-0170
关键词
biomarker; cardiovascular disease; continuous glucose monitoring; diabetes mellitus; diabetic complications; diagnosis; glucose; glycated hemoglobin; impaired fasting glucose; impaired glucose tolerance; microvascular complications
The clinical utility of diabetes biomarkers can be considered in terms of diagnosis, management and prediction of long-term vascular complications. Glucose satisfies all of these requirements. Thresholds of hyperglycemia diagnostic of diabetes reflect inflections that confer a risk of developing long-term microvascular complications. Degrees of hyperglycemia (impaired fasting glucose, impaired glucose tolerance) that lie below the diagnostic threshold for diabetes identify individuals at risk of progression to diabetes and/or development of atherothrombotic cardiovascular disease. Self-measured glucose levels usefully complement hemoglobin A(1c) levels to guide daily management decisions. Continuous glucose monitoring provides detailed real-time data that is of value in clinical decision making, assessing response to new diabetes drugs and the development of closed-loop artificial pancreas technology.
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