期刊
BIOMARKERS IN MEDICINE
卷 10, 期 11, 页码 1167-1179出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2016-0164
关键词
dietary intervention; dipeptidyl peptidase-4 inhibitor; gastric emptying; glucagon-like peptide-1; glucose-dependent insulinotropic polypeptide; incretin hormones; postprandial glycemia; Type 2 diabete
资金
- National Health and Medical Research Council (NHMRC) of Australia
- Royal Adelaide Hospital Research Committee Early Career Fellowship
- AstraZeneca
- Merck
- Eli Lilly
- Novartis
The GI tract is central to the regulation of postprandial glycemia, with the rate of gastric emptying and the secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, being key determinants. Gastric emptying exhibits a large interindividual variation; the latter not only accounts for differences in postprandial glycemia but also determines postprandial incretin profiles. Accordingly, the rate of gastric emptying may affect the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors. In contrast, glucagon-like peptide-1 receptor agonists lower postprandial glycemia predominantly by their action to slow gastric emptying. This review discusses the inter-relationship between gastric emptying and the incretin axis in the context of changes in blood glucose, with an emphasis on the relevant clinical implications.
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