期刊
BIOMARKERS
卷 22, 期 1, 页码 63-69出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1354750X.2016.1204005
关键词
Diagnosis; prognosis; sepsis; severe sepsis; septic shock; (soluble) triggering receptor expressed on myeloid cells
资金
- Department of Anaesthesiology (University of Heidelberg, Germany)
- Department of Medicine I and Clinical Chemistry (University of Heidelberg, Germany)
- Institute of Medical Biometry and Informatics (University of Heidelberg, Germany)
Objectives: The impact of TREM-1-mediated inflammation was investigated in different inflammatory settings. Methods: Secondary analyses of an observational clinical pilot study, including 60 patients with septic shock, 30 postoperative controls and 30 healthy volunteers. Results: Plasma levels of sTREM-1 were found to identify patients with septic shock more effectively than procalcitonin and C-reactive protein. Moreover, sTREM-1 was identified to be an early predictor for survival in patients with septic shock. Conclusion: Due to its diagnostic as well as prognostic value in sepsis syndrome, implementation of sTREM-1 measurements in routine diagnostics should be taken into account.
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