期刊
BIOMARKERS
卷 21, 期 7, 页码 639-644出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2016.1171907
关键词
Anti-inflammatory; cytokines; osteoarthritis; plasma; proinflammatory; synovial fluid
资金
- Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University [RA55/22]
- Thailand Research Fund
- National Research Council of Thailand
- Higher Education Research Promotion and National Research University Project of Thailand
- Office of the Higher Education Commission through the Aging Society Cluster, Chulalongkorn University [WCU-58-037-AS]
Objective: The objective of this study is to compare inflammatory cytokine levels in primary knee osteoarthritis (OA) patients and healthy controls. Methods: A total of 32 knee OA patients and 14 healthy controls were enrolled. A multiplex immunoassay was utilized for 10 cytokines in plasma and synovial fluid. Results: Plasma IL-2, IL-4, and IL-6 concentrations were significantly greater in knee OA patients than controls. Moreover, both plasma IL-4 and IL-6 were positively correlated with the radiographic severity of knee OA. Conclusions: Plasma IL-4 and IL-6 may serve as biomarkers reflecting the severity of OA.
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