期刊
BIOMARKERS
卷 21, 期 4, 页码 293-315出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2016.1141988
关键词
Internal exposure; liquid chromatography; mass spectrometry; mercapturic acid; toxicant metabolism; urinary biomarker
资金
- Intramural CDC HHS [CC999999] Funding Source: Medline
This review describes recent selected HPLC/MS methods for the determination of urinary mercapturates that are useful as noninvasive biomarkers in characterizing human exposure to electrophilic industrial chemicals in occupational and environmental studies. High-performance liquid chromatography/mass spectrometry is a sensitive and specific method for analysis of small molecules found in biological fluids. In this review, recent selected mercapturate quantification methods are summarized and specific cases are presented. The biological formation of mercapturates is introduced and their use as indicators of metabolic processing of reactive toxicants is discussed, as well as future trends and limitations in this area of research.
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