Prognostic significance of insulin-like growth factor-I serum levels in acute decompensation of cirrhosis

Context: IGF-I serum levels are suppressed in cirrhosis, but its prognostic significance is unknown. Objectives: To investigate the prognostic value of IGF-I in patients admitted for acute decompensation of cirrhosis. Materials and methods: Cohort study that included 103 patients. IGF-I was measured by enzymelinked immunosorbent assay (ELISA). Results: Ninety-day mortality was 26.2% and it was independently associated with MELD, age and IGFI. The Kaplan-Meier survival probability at 90 days was 94.3% in patients with IGF-I >= 13 mu g/mL and 63.2% for patients with IGF-I < 13 ng/mL (p = .001). Discussion and conclusion: IGF-I levels are independently associated with mortality in acute decompensation of cirrhosis.