期刊
FITOTERAPIA
卷 138, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fitote.2019.104341
关键词
Huperzine A; Biotransformation; Irpex lacteus; Huperzia serrata
资金
- Natural Science Foundation of Zhejiang Province [LY17B020011]
- Natural Science Foundation of China [21402174]
The biotransformation of huperzine A (hupA), one of the characteristic bioactive constituents of the medicinal plant Huperzia serrata, by a fungal endophyte of the host plant was studied. Two previously undescribed compounds 1-2, along with a known analog 8 alpha,15 alpha-epoxyhuperzine A (3), were isolated and identified. The structures of all the isolates were established by spectroscopic methods including NMR, MS, IR, and UV spectra. In particular, the absolute configurations of 1 and 2 were elucidated by CD spectra comparison and theoretic NOE strength calculation. In the LPS-induced neuro-inflammation injury assay, 1-3 exhibited moderate neuroprotective activity by increasing the viability of U251 cell lines with EC50 values of 35.3 +/- 0.9, 32.1 +/- 0.9, and 50.3 +/- 0.8 nM, respectively.
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