期刊
FISH & SHELLFISH IMMUNOLOGY
卷 93, 期 -, 页码 436-448出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2019.07.076
关键词
Scylla paramamosain; Innate immunity; Pattern recognition; Signaling pathway; Antimicrobial peptides; Antioxidant system
资金
- National Natural Science Foundation of China (NSFC) [41806162/1J1805233]
- Fujian Science and Technology Department [2017NZ0004/2017NZ0004-1]
- Fundamental Research Funds for the Central Universities [20720180100/20720180117]
Mud crabs, Scylla paramamosain, are one of the most economical and nutritious crab species in China and South Asia. Inconsistent with the high development of commercial mud crab aquaculture, effective immunological methods to prevent frequently-occurring diseases have not yet been developed. Thus, high mortalities often occur throughout the different developmental stages of this species resulting in large economic losses. In recent years, numerous attempts have been made to use various advanced biological technologies to understand the innate immunity of S. paramamosain as well as to characterize specific immune components. This review summarizes these research advances regarding cellular and humoral responses of the mud crab during pathogen infection, highlighting hemocytes and gills defense, pattern recognition, immune-related signaling pathways (Toll, IMD, JAK/STAT, and prophenoloxidase (proPO) cascades), immune effectors (antimicrobial peptides), production of reactive oxygen species and the antioxidant system. Diseases affecting the development of mud crab aquaculture and potential disease control strategies are discussed.
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